ReSEARCH BAM


Entwicklung einer automatisierten on-line CE Multikollektor-ICP-MS Kopplung für die speziesspezifische Isotopenverhältnisanalyse von Biomolekülen
Projektleitung
	Dr. rer. nat. Björn Meermann BAM - 1.1 Anorganische Spurenanalytik E-Mail: Bjoern.Meermann@bam.de
Förderstruktur
	DFG - DFG - Sachbeihilfen
Projektbeginn
	01.02.2021
Projektende
	30.04.2024
Projektart
	Realisierte Antragsforschung
Themen-/Aktivitätsfeld
	THEMENFELD Analytical Sciences, * Spurenanalytik und chemische Zusammensetzung
Abstract
	Up to now, only a few studies have dealt with species-specific isotopic analysis by on-line hyphenation with MC-ICP-MS and only one with CE/MC-ICP-MS. However, this field holds great potential in varying research areas. This project will focus on the use of CE/MC-ICP-MS for the simultaneous isotopic analysis of elemental species, especially S, as it is the only target element for ICP-MS in all proteins in biological systems and is also present in peptides and smaller important biomolecules. Isotope variations of S in biomolecules could be used for the elucidation and tracing of biological processes, as well as help diagnosing diseases and monitoring treatment progress. Furthermore, the proposed method will foster the development of certified reference materials in bioresearch and support metrology activities in this research area.